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Although all authors agree for the presence of GLP1R in the pancreatic islets, there are differences at the level of ducts: whereas Körner et al , 2 Pyke et al , 24 and Drucker, 11 using GLP1R autoradiography, immunohistochemistry, or mRNA analysis, respectively, were unable to detect GLP1R in human ducts, Gier et al 25 found such receptors in rat and human pancreatic ducts by immunohistochemistry

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Glucose-6-phosphatase (G6Pase) contributes to hyperglycemia in diabetes mellitus and regulates the rate-limiting steps in hepatic gluconeogenic flux (Herling et al., 1998)